Fohlmeister JF, Miller RF.
Impulse encoding mechanisms of ganglion cells in the
tiger salamander retina.
J Neurophysiol 1997 Oct;78(4):1935-47
A reprint of this article can be obtained from
This model is initially setup to produce figure 1 automatically.
After viewing the currents, you may simulate figure 3a in the
1) close the 6 graph windows.
2) Destroy the SEClamp object by executing the statement
3) Select the
menuitem and double click on the
4) press the Init&Run button.
The following parameter changes to the current working code supplied
by Bob Miller's lab were made in collaboration with
Michael Hines in order to
semi-quantitatively reproduce figures 1 and 3a.
1) Table 1 indicates that gnabar_spike = .05 S/cm2. However the curves
for the Na-current portion of Fig 1 use the default mod file value of
gnabar_spike = .04 .
2) The initial Ca Rev. Potential of Fig 1 requires that the Table 1 value
of celsius = 22 degC be used instead of NEURON's default value of 6.3.
This statement was added to the current.hoc file.
3) To get the fig 1 behavior of slowly increasing calcium concentration
with constant calcium current over 10 ms we modified current.hoc so that
depth_cad = 3 (microns)
taur_cad = 10 (ms)
instead of the working code values of 2.5 and 1.5 respectively.
4) The working code used a spherical soma of 5um in diameter. This
was changed to 25um as indicated in the paper and gives the results
of fig 3 when a current of .02 nA is injected which is the amount
specified in the paper.
The largest discrepancy is
that the amplitude of Ca-activated K-current is lower
in this example model than is indicated in fig 1 of the paper.
Questions about how to execute the model should be addressed to
email@example.com. Questions about parameters should
be addressed to
J. F. Fohlmeister,
6-255 Millard Hall
University of Minnesota
435 Delaware St. SE.
Minneapolis, MN 55455
20120109 capump.mod updated from euler to derivimplicit: see for more:
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592 - TMM
20130826 Update from Ted Carnevale: capump.mod cleaned up to 1)
reflect this mechanism is just a simple calcium accumulation mechanism
that approximates pump action by a first order decay of cai and 2)
since neither drive_pump nor kt were used for anything, every mention
of them was deleted for clarity's sake.
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