ModelDB: Paired turbulence and light effect on calcium increase in Hermissenda (Blackwell 2004)

Paired turbulence and light effect on calcium increase in Hermissenda (Blackwell 2004)

Accession: 53427

The sea slug Hermissenda learns to associate light and hair cell stimulation, but not when the stimuli are temporally uncorrelated...These issues were addressed using a multi-compartmental computer model of phototransduction, calcium dynamics, and ionic currents of the Hermissenda photoreceptor...simulations show that a potassium leak channel, which closes with an increase in calcium, is required to produce both the untrained LLD and the enhanced LLD due to the decrease in voltage dependent potassium currents.
Reference: Blackwell KT (2004) Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda. J Comput Neurosci 17:81-99 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):	Type B photoreceptor;
Channel(s):	I A; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):	GabaA; GabaB;
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	Chemesis;
Model Concept(s):	Temporal Pattern Generation; Invertebrate; Signaling pathways; Calcium dynamics;
Implementer(s):	Blackwell, Avrama [avrama at gmu.edu];

Search NeuronDB for information about: GabaA; GabaB; I A; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba;

Model files

Help downloading and running models

pumpsoma-axon3-cicr3.g

pumpsoma-axon3-serca18.g

pumpsoma-axon5-ISIcurve.g

Chemesis scripts used for simulations in "Paired Turbulence and Light do
not Produce a Supralinear Calcium Increase in Hermissenda." J
Computational Neuroscience 2004 Jul-Aug;17(1):79-97

See 
http://www.gmu.edu/departments/krasnow/CENlab/index.html 

This model requires the Genesis extension from chemesis2.0.tar.gz.

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University