ModelDB: CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)

CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)

Accession: 55035

NEURON mod files from the paper: M. Migliore, M. Ferrante, GA Ascoli (2005). The model shows how the back- and forward propagation of action potentials in the oblique dendrites of CA1 neurons could be modulated by local properties such as morphology or active conductances.
Reference: Migliore M, Ferrante M, Ascoli GA (2005) Signal propagation in oblique dendrites of CA1 pyramidal cells. J Neurophysiol 94:4145-4155 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	Neuron; neuroConstruct (web link to model);
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA1 pyramidal neuron; AMPA; I Na,t; I A; I K; I h; Glutamate;

Model files

Help downloading and running models

NEURON mod files from the paper:

Migliore M, Ferrante M, Ascoli GA (2005) 
Signal propagation in oblique dendrites of CA1 pyramidal cells.
J Neurophysiol 94:4145-4155

The model shows how the back- and forward propagation of action potentials 
in the oblique dendrites of CA1 neurons could be modulated by local properties 
such as morphology or active conductances.
The simulation reproduces Fig.2A of the paper, using neuron 5038804:





Morphology files for all the neurons used in this paper can be found at:
http://krasnow.gmu.edu/L-Neuron


Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui fig2A.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
fig2A.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University