ModelDB: Midbrain dopamine neuron: firing patterns (Canavier 1999)

Midbrain dopamine neuron: firing patterns (Canavier 1999)

Accession: 6763

Sodium dynamics drives the generation of slow oscillations postulated to underly NMDA-evoked bursting activity.
Reference: Canavier CC (1999) Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci 6:49-69 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):	Nigral dopaminergic cell;
Channel(s):	Na/K pump;
Gap Junctions:
Receptor(s):	NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Activity Patterns; Oscillations; Sodium pump;
Implementer(s):	Canavier, CC;

Search NeuronDB for information about: Nigral dopaminergic cell; NMDA; Na/K pump;

Model files

Help downloading and running models

This is the README for the model associated with the paper:

Canavier CC. (1999).  Sodium dynamics underlying burst firing and
putative mechanisms for the regulation of the firing pattern in
midbrain dopamine neurons: a computational approach.  J Comput
Neurosci. 6:49-69

These model files were created by Dr Canavier.

This example (after reaching steady oscillation) produces trajectories
corresponding to Figure 5 A2. and Figure 6.

The out.gif file shows the time plots generated by the example:



Usage:
Simply auto-launch from ModelDB or compile the mod files under

MSWIN:
-----

Use mknrndll (change directory to the one expanded from the archive
and click "make nrnmech.dll").  Then run by double clicking the
mosinit.hoc file in a windows explorer.

MAC OS X
--------

Drag and drop the expanded folder from this archive onto the mknrndll
icon.  Drag and drop the mosinit.hoc file onto the nrngui icon.

Linux/Unix
----------

Change directory to the expanded folder and type these two lines:
nrnivmodl
nrngui mosinit.hoc

Once the simulation is started
------------------------------

Press the init & run button to generate the above figure.

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