ModelDB: Cardiac Atrial Cell (Courtemanche et al 1998) (C++)

Cardiac Atrial Cell (Courtemanche et al 1998) (C++)

Accession: 79461

The mechanisms underlying many important properties of the human atrial action potential (AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents based on data recorded from human atrial myocytes, along with representations of pump, exchange, and background currents, we developed a mathematical model of the AP. The model AP resembles APs recorded from human atrial samples and responds to rate changes, L-type Ca2+ current blockade, Na+/Ca2+ exchanger inhibition, and variations in transient outward current amplitude in a fashion similar to experimental recordings. Rate-dependent adaptation of AP duration, an important determinant of susceptibility to atrial fibrillation, was attributable to incomplete L-type Ca2+ current recovery from inactivation and incomplete delayed rectifier current deactivation at rapid rates. Experimental observations of variable AP morphology could be accounted for by changes in transient outward current density, as suggested experimentally. We conclude that this mathematical model of the human atrial AP reproduces a variety of observed AP behaviors and provides insights into the mechanisms of clinically important AP properties.
Reference: Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Acetylcholine;
Simulation Environment:	C or C++ program;
Model Concept(s):	Ion Channel Kinetics; Action Potentials; Pathophysiology; Heart disease; Sodium pump;
Implementer(s):	Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Lai, Hsing-Jung ;

Search NeuronDB for information about: I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/K pump; Acetylcholine;

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This is the readme.html for the model associated with the paper

Courtemanche M, Ramirez RJ, Nattel S. 
Ionic mechanisms underlying human atrial action potential 
properties: insights from a mathematical model. 
Am J Physiol Heart Circ Physiol 2006:275;H301.

Abstract:

The mechanisms underlying many important properties of the human
atrial action potential (AP) are poorly understood. Using specific
formulations of the K+, Na+, and Ca2+ currents based on data recorded
from human atrial myocytes, along with representations of pump,
exchange, and background currents, we developed a mathematical model
of the AP. The model AP resembles APs recorded from human atrial
samples and responds to rate changes, L-type Ca2+ current blockade,
Na+/Ca2+ exchanger inhibition, and variations in transient outward
current amplitude in a fashion similar to experimental
recordings. Rate-dependent adaptation of AP duration, an important
determinant of susceptibility to atrial fibrillation, was attributable
to incomplete L-type Ca2+ current recovery from inactivation and
incomplete delayed rectifier current deactivation at rapid
rates. Experimental observations of variable AP morphology could be
accounted for by changes in transient outward current density, as
suggested experimentally. We conclude that this mathematical model of
the human atrial AP reproduces a variety of observed AP behaviors and
provides insights into the mechanisms of clinically important AP
properties.

As the beat of stimulus was 50 at a cycle lingth of 1000 ms, the
simulation will make graph 



similar to the result in the model of
NEURON by Ingemar Jacobson.

This C++ code was submitted by:

Hsing-Jung Lai and Dr. Sheng-Nan Wu 
National Cheng Kung University Medical Center
Tainan, 70101, Taiwan
i5492111@ccmail.ncku.edu.tw (Hsing-Jung Lai)
snwu@mail.ncku.edu.tw (Sheng-Nan Wu)

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