ModelDB: CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)

CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)

Accession: 87546

The model supports the experimental findings showing that the dynamic interaction between cells with various firing patterns could differently affect GABAergic signaling, leading to a wide range of interneuronal communication within the hippocampal network.
Reference: Minneci F, Janahmadi M, Migliore M, Dragicevic N, Avossa D, Cherubini E (2007) Signaling properties of stratum oriens interneurons in the hippocampus of transgenic mice expressing EGFP in a subset of somatostatin-containing cells. Hippocampus 17:538-53 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:
Cell Type(s):	CA1 oriens alveus interneuron;
Channel(s):	I A; I Sodium; I Potassium;
Gap Junctions:	Gap junctions;
Receptor(s):	Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Activity Patterns; Bursting; Active Dendrites; Detailed Neuronal Models; Action Potentials; Signaling pathways;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA1 oriens alveus interneuron; Gaba; I A; I Sodium; I Potassium;

Model files

Help downloading and running models

NEURON mod files from the paper:

Federico Minneci, Mahyar Janahmadi, Michele Migliore, Natasa
Dragicevic, Daniela Avossa, and Enrico Cherubini, Signaling properties
of stratum oriens interneurons in the hippocampus of transgenic mice
expressing EGFP in a subset of somatostatin-containing cells,
Hippocampus 17:538-553 (2007).

The simulation file can be used to reproduce the traces in Fig.10c of
the paper, modeling the effects of electrical coupling between cells
with various firing patterns.  In the simulation window, "amp. reg"
and "amp.clust." are the amplitude of the current injection in the
regular or cluster type of interneuron, respectively.  ggap is the gap
junctional conductance of each gap junction.  The default values of
the parameters reproduce the middle trace in Fig.10c


Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui forfig-10c.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
forfig-10c.hoc 
will open the simulation window.

Running the model in the default setting displays:



Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University