SenseLab Home ModelDB Home

Dentate gyrus granule cell: subthreshold signal processing (Schmidt-Hieber et al. 2007)
Accession: 95960
Detailed compartmental cable models of 8 hippocampal granule cells of adult mice were obtained from dual patch-clamp whole-cell recordings and subsequent 3D reconstructions. This code allows to reproduce figures 6-8 from the paper.
Reference: Schmidt-Hieber C, Jonas P, Bischofberger J (2007) Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells. J Neurosci 27:8430-41 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):  Dentate granule cell;  
Channel(s):   
Gap Junctions:  
Receptor(s):  AMPA; Glutamate;
Gene(s):  
Transmitter(s):  Glutamate;
Simulation Environment:  Neuron;
Model Concept(s):  Parameter Fitting; Influence of Dendritic Geometry; Synaptic Integration;
Implementer(s):  Schmidt-Hieber, Christoph [christoph.schmidt-hieber at uni-freiburg.de];
Search NeuronDB for information about:  Dentate granule cell; AMPA; Glutamate; Glutamate;
\
gc-1.1
cell_1
cell_2
cell_3
cell_4
cell_5
cell_6
cell_7
cell_8
share
README.txt
asin.mod
spines.mod
synampa.mod
mosinit.hoc
gc.hoc
ChangeLog.txt
INSTALL.txt
                            
These simulations accompany the publication:

Schmidt-Hieber C, Jonas P, Bischofberger J (2007)
Subthreshold Dendritic Signal Processing and Coincidence Detection 
in Dentate Gyrus Granule Cells. J Neurosci 27:8430-8441

For installation instructions, see INSTALL.txt

Simulations have been tested using NEURON 5.9 and 6.0 under
Windows and GNU/Linux. The gnuplot script has been tested with
gnuplot 4.2 (http://www.gnuplot.info).

Send bug reports and comments to
christoph.schmidt-hieber@uni-freiburg.de

Description of files:
./gc.hoc                   Starts the simulations. Requires mod files to be compiled.
./asin.mod                 arcsine function, forwarded to hoc from math.h
./spines.mod               Introduces spine area scale factor as a range variable
                           (scale_spines).
                           Optionally, spine counts can be used as a range variable
                           as well (count_spines).
./synampa.mod              Synaptic conductance change with a biexponential time course.
./share/calcSpines.hoc     Calculate spine area scale factor from spine counts. Corrects
                           for spines hidden behind the shaft in 2D projections.
./share/config.hoc         Simulation configuration settings.
./share/controlpanel.hoc   Main control panel allowing cell and figure selection.
./share/figures.hoc        Procedures reproducing figures.
./share/fixnseg.hoc        d_lambda rule implementation.
./share/genutils.hoc       Some general-purpose routines.
./share/spine.hoc          Creates a spine, consisting of a neck (spine[0]) and a
                           head (spine[1])
./share/template.plt       Template script file for creating a gnuplot script that
                           will show a 3D plot as in figure 6D.
./cell_x/membrane.hoc      Loads cell morphology and connections, initializes spines,
                           inserts passive membrane properties. Uses a class "cell_x"
                           so that you can easily toggle between cells or use multiple
                           objects for network simulations.
./cell_x/morpho.hoc        Loads morphology and spines without making use of a class.
                           Intended for standalone use of cells.
./cell_x/morpho.txt        Coordinates and diameters of 3D points as plain text. Needed
                           by membrane.hoc to load 3D morphology from a procedure.

20071005
Cell templates now adhere to the "NetworkReadyCell" syntax - fixed some minor bugs. Schmidt-Hieber.


ModelDB Home  SenseLab Home   Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University