ModelDB: Site of impulse initiation in a neuron (Moore et al 1983)

Site of impulse initiation in a neuron (Moore et al 1983)

Accession: 9852

Examines the effect of temperature, the taper of the axon hillock, and HH channel density on antidromic spike invasion into the soma and spike initiation under dendritic stimulation.
Reference: Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Spinal motor neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Simplified Models;
Implementer(s):	Hines, Michael [Michael.Hines at Yale.edu];

Search NeuronDB for information about: Spinal motor neuron; I Na,t; I K;

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Moore, Stockbridge, and Westerfield. (1983) On the site of impulse initiation
in a neurone. 
J. Physiol. 336: 301-311.

This model qualitatively reproduces figures 1-5.
Note that orthodromic stimulus amplitude is considerably different from
that noted in the paper. IClamp[0].amp was chosen to give qualitative similarity.
We attribute minor quantitative differences to the following:
1) The precise site of axon v vs t curve is not specified. We plot
axon.v(0.25).
2) The antidromic stimulus was unspecified.


The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.

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