ModelDB: Olfactory Mitral Cell (Davison et al 2000)

Olfactory Mitral Cell (Davison et al 2000)

Accession: 2487

A four-compartment model of a mammalian olfactory bulb mitral cell, reduced from the complex 286-compartment model described by Bhalla and Bower (1993). The compartments are soma/axon, secondary dendrites, primary dendrite shaft and primary dendrite tuft. The reduced model runs 75 or more times faster than the full model, making its use in large, realistic network models of the olfactory bulb practical.
Reference: Davison AP, Feng J, Brown D (2000) A reduced compartmental model of the mitral cell for use in network models of the olfactory bulb. Brain Res Bull 51:393-9 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Olfactory bulb mitral cell;
Channel(s):	I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Parameter Fitting; Simplified Models;
Implementer(s):	Davison, Andrew ;

Search NeuronDB for information about: Olfactory bulb mitral cell; I A; I Calcium; I K; I K,Ca; I K,leak; I L high threshold; I Na,t; I Potassium; I Sodium;

Model files

Help downloading and running models

Mitral cell model with four compartments
(soma/axon, secondary dendrites, primary dendrite shaft, primary dendrite tuft)
from: Davison AP, Feng J and Brown D. (2000) A reduced compartmental model of
      the mitral cell for use in network models of the olfactory bulb.
      Brain Research Bulletin 51(5): 393-399.

Run the model using the file mosinit.hoc after compiling the .mod files.

The graphs from fig. 6 in the paper can be reproduced by clicking the buttons
labelled "Stimulate soma with 0.2 uA/cm2" etc.

A panel allows the parameters p, q, r, g_pg, g_sp, g_sd, alpha_s and alpha_g
to be varied.

Please note there are some typos in the paper:
(1) The current balance equation for Vd should be
	Cm Vd' = -Ileak - INa - IKfast + (gsd/s)(Vs-Vd)
    not
	Cm Vd' = -Ileak - INa - IKfast - (gsd/s)(Vs-Vd)

(2) In Table 1, g_pg should be 4.08 x 10^-4, not 4.08 x 10^-3


For more information contact 

andrew.davison@yale.edu

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