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 Neostriatal spiny neuron
Mode: Overview Data/Search plus Connectivity plus Classical References/Notes Models BrainPharm
Region:
Distal equivalent dendrite Middle equivalent dendrite Proximal equivalent dendrite Soma Axon hillock Axon fiber Axon terminal All Compartments
Properities: Receptors Channels Transmitters All Properties
Interoperation: Gene and Chromosome
Are:
 Present   Absent 
Neuron Type: principal
Organism: Vertebrates
Input Receptors
Soma
Gaba
GABAergic responses evoked by electrical stimulations have been studied in slices (Kita and Kita H and Kitai ST, 1985245 ).
D2
Activation of both D1- and D2-class receptors has been shown to modulate potassium and sodium currents in acutely isolated neostriatal neurons (Surmeier DJ and Kitai ST, 1993238 ).
Muscarinic
Recording from dissociated neurons using intracellular and whole-cell voltage-clamp recordings showed that carbachol can act at M1-like muscarinic receptors to reduce the membrane K+ conductances and excite the neostriatal neurons (Hsu KS, Yang C and Huang CC and Gean PW, 1996 [rat]247 ).
D1
Activation of both D1- and D2-class receptors has been shown to modulate potassium and sodium currents in acutely isolated neostriatal neurons (Surmeier DJ and Kitai ST, 1993238 ).Recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance (Hernandez-Lopez S, Bargas J, Surmeier D and Reyes A and Galarraga E, 1997241 ).
Classical References: first publications on each compartmental property; search PubMed for complete list
238.Surmeier DJ and Kitai ST. (1993) D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons. Prog Brain Res. 99:309-324.
241.Hernandez-Lopez S, Bargas J, Surmeier D and Reyes A and Galarraga E. (1997) D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance. J Neurosci. 17:9:3334-3342.
245.Kita and Kita H and Kitai ST. (1985) Local stimulation induced GABAergic response in rat striatal slice preparations: intracellular recordings on QX-314 injected neurons. Brain Res. 360:1-2:304-310.
247.Hsu KS, Yang C and Huang CC and Gean PW. (1996) Carbachol induces inward current in neostriatal neurons through M1-like muscarinic receptors. Neuroscience. 73:3:751-760.
 
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