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 Nigral dopaminergic cell
Mode: Overview Data/Search plus Connectivity plus Classical References/Notes Models BrainPharm
Region:
Distal apical dendrite Middle apical dendrite Proximal apical dendrite Distal basal dendrite Middle basal dendrite Proximal basal dendrite Soma Axon hillock Axon fiber Axon terminal All Compartments
Properities: Receptors Channels Transmitters All Properties
Interoperation: Gene and Chromosome
Are:
 Present   Absent 
Neuron Type: principal
Organism: Vertebrates
Intrinsic Currents
Middle apical dendrite
I p,q
The action potential has a pronounced Ca component on its falling phase (Yung W and Hausser MA and Jack JJ, 1991 [guinea pig]41 ; reviewed in Hausser M, Stuart and Racca C and Sakmann B, 1995 [rat]40 ).Yung W and Hausser MA and Jack JJ, 1991 [guinea pig]41 , Geffen LB, Jessell TM, Cuello A and Iversen LL, 1976 [rat]42 , Stuart and Sakmann B, 1994 [rat]43
I Calcium
Using differential polarization through applied electric fields, cell bodies and dendrites have been activated in effective isolation during intracellular recordings in vitro. In neurons located in the rostral substantia nigra, the dendrites are shown to have both HVA and LVA channels. HVA conductance appears to be exclusively dendritic. By contrast, in more caudally located cells HVA calcium spikes were located principally in the cell body (Hounsgaard and Nedergaard S and Greenfield SA, 1992280 ).
I Na,t
"the back-propagating action potential may be important for the dendritic release of dopamine" (Hausser M, Stuart and Racca C and Sakmann B, 1995 [rat]40 ).
Classical References: first publications on each compartmental property; search PubMed for complete list
40.Hausser M, Stuart and Racca C and Sakmann B. (1995) Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron. 15:3:637-647.
41.Yung W and Hausser MA and Jack JJ. (1991) Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro. J Physiol. 436:643-667.
42.Geffen LB, Jessell TM, Cuello A and Iversen LL. (1976) Release of dopamine from dendrites in rat substantia nigra.. Nature. 260:5548:258-260.
43.Stuart and Sakmann B. (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites.. Nature. 367:6458:69-72.
280.Hounsgaard and Nedergaard S and Greenfield SA. (1992) Electrophysiological localization of distinct calcium potentials at selective somatodendritic sites in the substantia nigra. Neuroscience. 50:3:513-518.
 
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