Back User:Public     

 Nigral dopaminergic cell
Mode: Overview Data/Search plus Connectivity plus Classical References/Notes Models BrainPharm
Region:
Distal apical dendrite Middle apical dendrite Proximal apical dendrite Distal basal dendrite Middle basal dendrite Proximal basal dendrite Soma Axon hillock Axon fiber Axon terminal All Compartments
Properities: Receptors Channels Transmitters All Properties
Interoperation: Gene and Chromosome
Are:
 Present   Absent 
Neuron Type: principal
Organism: Vertebrates
Intrinsic Currents
Soma
I K,Ca
Intracellular recordings showed that Apamin-sensitive IKCa regulate pacemaker activity in these neurons (Ping HX and Shepard PD, 1996 [rat]279 ).
I p,q
The action potential has a pronounced Ca component on its falling phase (Yung W and Hausser MA and Jack JJ, 1991 [guinea pig]41 ; reviewed in Hausser M, Stuart and Racca C and Sakmann B, 1995 [rat]40 ).
I Calcium
Using differential polarization through applied electric fields, cell bodies and dendrites have been activated in effective isolation during intracellular recordings in vitro. In neurons located in the rostral substantia nigra, the dendrites are shown to have both HVA and LVA channels. HVA conductance appears to be exclusively dendritic. By contrast, in more caudally located cells HVA calcium spikes were located principally in the cell body (Hounsgaard and Nedergaard S and Greenfield SA, 1992280 ).
I Na,t
Classical References: first publications on each compartmental property; search PubMed for complete list
40.Hausser M, Stuart and Racca C and Sakmann B. (1995) Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron. 15:3:637-647.
41.Yung W and Hausser MA and Jack JJ. (1991) Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro. J Physiol. 436:643-667.
279.Ping HX and Shepard PD. (1996) Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. Neuroreport. 7:3:809-814.
280.Hounsgaard and Nedergaard S and Greenfield SA. (1992) Electrophysiological localization of distinct calcium potentials at selective somatodendritic sites in the substantia nigra. Neuroscience. 50:3:513-518.
 
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
Link Graphic to NIF website Human Brain Project Yale Center for Medical Informatics Questions, comments, problems? Email the Database Administrator
This site is Copyright 2012, Yale Center for Medical Informatics		 National Institutes of Health Department of Health and Human Services