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 CN pyramidal (fusiform) cell
Mode: Overview Data/Search plus Connectivity plus Classical References/Notes Models BrainPharm
Region:
Distal apical dendrite Middle apical dendrite Proximal apical dendrite Distal basal dendrite Middle basal dendrite Proximal basal dendrite Soma Axon hillock Axon fiber Axon terminal All Compartments
Properities: Receptors Channels Transmitters All Properties
Interoperation: Gene and Chromosome
Are:
 Present   Absent 
Neuron Type: principal
Organism: Vertebrates
Input Receptors
Proximal apical dendrite
NMDA
Immunocytochemistry and in situ hybridisation showed that NMDAR1 was expressed in most CN neuronal types, including the fusiform cell apical dendrites. However, fusiform cell basal dendrites, which are the synaptic sites of cochlear nerve fibers, did not express NMDAR1 (Bilak M and Bilak SR and Morest DK, 1996 [mouse]266 ).
Granule Cell terminals (T)Glutamate
All levels of the apical dendrites receive input from granule cells (which receive their input from mossy fibers); the terminals make small spherical vesicle (ss) synapses (Smith P and Rhode WS, 1985 [cat]97 ) on spines (SOBiv p126,130). The neurotransmitter is GLU (Hunter C, Petralia RS, Vu and Wenthold RJ, 1993 [mammal]98 ; Osen KK, Storm-Mathisen J, Ottersen O and Dihle B, 1995 [guinea pig]99 ; Manis P and Molitor SC, 1996 [mammal]100 ) (SOBiv p128). Granule cells are similar to cerebellar granule cells (SOBiv p132).
Cartwheel Cell terminals (T)Glycine
Soma and proximal apical dendrites receive mainly flattened (FL) or pleiomorphic (PL) vesicle synapses on their trunks. These are correlated with IPSPs (SOBiv p128,130-1). Cartwheel cells stain for CLY (Osen KK, Ottersen O and Storm-Mathisen J, 1990101 ; lighter staining for GABA/GAD; SOBiv p132). Cartwheel cells produce IPSPs in pyramidal cells (see Golding N and Oertel D, 1995102 ) (also in giant cells, and they interact with each other; SOBiv p135). Cartwheel cells are the second most numerous cell in the DCN, after the granule cells (SOBiv p135).
Cartwheel Cell terminals (T)Gaba
Soma and proximal apical dendrites receive mainly flattened (FL) or pleiomorphic (PL) vesicle synapses on their trunks. These are correlated with IPSPs (SOBiv p128,130-1). Cartwheel cells stain for CLY (Osen KK, Ottersen O and Storm-Mathisen J, 1990101 ; lighter staining for GABA/GAD; SOBiv p132). Cartwheel cells produce IPSPs in pyramidal cells (see Golding N and Oertel D, 1995102 ) (also in giant cells, and they interact with each other; SOBiv p135). Cartwheel cells are the second most numerous cell in the DCN, after the granule cells (SOBiv p135).
AMPA
AMPA receptors postsynaptic to the auditory nerve have relatively fast decay kinetics (Gardner S and Trussell LO and Oertel D, 2001574 ).
Classical References: first publications on each compartmental property; search PubMed for complete list
97.Smith P and Rhode WS. (1985) Electron microscopic features of physiologically characterized, HRP-labeled fusiform cells in the cat dorsal cochlear nucleus.. J Comp Neurol. 237:1:127-143.
98.Hunter C, Petralia RS, Vu and Wenthold RJ. (1993) Expression of AMPA-selective glutamate receptor subunits in morphologically defined neurons of the mammalian cochlear nucleus.. J Neurosci. 13:5:1932-1946.
99.Osen KK, Storm-Mathisen J, Ottersen O and Dihle B. (1995) Glutamate is concentrated in and released from parallel fiber terminals in the dorsal cochlear nucleus: a quantitative immunocytochemical analysis in guinea pig.. J Comp Neurol. 3:357:482-500.
100.Manis P and Molitor SC. (1996) N-methyl-D-aspartate receptors at parallel fiber synapses in the dorsal cochlear nucleus.. J Neurophysiol. 76:3:1639-1656.
101.Osen KK, Ottersen O and Storm-Mathisen J. (1990) In: Glycine Neurotransmission.. . .
102.Golding N and Oertel D. (1995) Evidence that cartwheel cells of the dorsal cochlear nucleus excite other cartwheel cells and inhibit principal cells with the same neurotransmitter, glycine.. Abstr Soc Neurosci. 21:399.
266.Bilak M and Bilak SR and Morest DK. (1996) Differential expression of N-methyl-D-aspartate receptor in the cochlear nucleus of the mouse. Neuroscience. 75:4:1075-1097.
574.Gardner S and Trussell LO and Oertel D. (2001) Correlation of AMPA receptor subunit composition with synaptic input in the mammalian cochlear nuclei. J Neurosci. 21:18:7428-37.
 
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