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 Cerebellar granule cell
Mode: Overview Data/Search plus Connectivity plus Classical References/Notes Models BrainPharm
Region:
Distal equivalent dendrite Middle equivalent dendrite Proximal equivalent dendrite Soma Axon hillock Axon fiber Axon terminal All Compartments
Properities: Receptors Channels Transmitters All Properties
Interoperation: Gene and Chromosome
Are:
 Present   Absent 
Neuron Type: interneuron
Organism: Vertebrates
Intrinsic Currents
Soma
I Potassium
Granule cells that lack GABAA receptors (in somatic location? ) express the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance, so as to maintain normal neuronal behaviour (Brickley SG, Revilla V, Cull-Candy S and Wisden W and Farrant M, 2001418 ). Importance for membrane excitability of an GABAB receptor-activated inward-rectifying potassium current, sensitive to pertussis toxin and barium (Slesinger PA, Stoffel and Jan YN and Jan LY, 1997419 ). Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (Cull-Candy S and Marshall CG and Ogden D, 1989430 ). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (Jalonen T, Johansson S, Holopainen and Oja SS and Arhem P, 1990429 ).
I A
Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (Cull-Candy S and Marshall CG and Ogden D, 1989430 ). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (Jalonen T, Johansson S, Holopainen and Oja SS and Arhem P, 1990429 ) Presence of Subthreshold-operating transient (A-type) K(+) currents (I(SA)s), as indicated by an accesspry subunit that accelerates the kinetics of this current (Nadal MS, Amarillo and Vega-Saenz de Miera E and Rudy B, 2001428 ).
I Na,t
Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (Cull-Candy S and Marshall CG and Ogden D, 1989430 ). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (Jalonen T, Johansson S, Holopainen and Oja SS and Arhem P, 1990429 )
Classical References: first publications on each compartmental property; search PubMed for complete list
418.Brickley SG, Revilla V, Cull-Candy S and Wisden W and Farrant M. (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature. 409:6816:88-92.
419.Slesinger PA, Stoffel and Jan YN and Jan LY. (1997) Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc Natl Acad Sci U S A. 94:22:12210-12217.
428.Nadal MS, Amarillo and Vega-Saenz de Miera E and Rudy B. (2001) Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor. J Physiol. 537:Pt 3:801-809.
429.Jalonen T, Johansson S, Holopainen and Oja SS and Arhem P. (1990) Single-channel and whole-cell currents in rat cerebellar granule cells. Brain Res. 535:1:33-38.
430.Cull-Candy S and Marshall CG and Ogden D. (1989) Voltage-activated membrane currents in rat cerebellar granule neurones. J Physiol. 414:179-199.
 
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