NeuronDB = Neocortical basket cell - plus Classical References/Notes

Output Transmitters

Axon terminal

to other GABAergic interneurons; with spiny neurons (reciprocally); Autaptic self-innervation

Layer-4 basket cell axons make lateral connection isotropically near cell body ( 50 microm radius), but beyond this core region, anisotropically, preferably within a particular angular sectors cell body (Budd JM and Kisvarday ZF, 2001⁴⁴¹ ). GABA inactivation of large-basket cells of visual cortex resulted in weakened orientation and direction selectivity, via weakening of long-range lateral inhibition by the basket cells (Kisvarday ZF, Crook J and Buzas P and Eysel UT, 2000⁴⁴² ). GABAergic interneurons (basket cells, dendrite-targeting cells, and double-bouquet cells) form reciprocally interconnected intracortical networks in which basket cells play a prominent role, given the strength of innervation and the proximal placement of synapses by basket cells to their postsynaptic targets (Tamas and Somogyi P and Buhl EH, 1998⁴⁴⁴ ). Layer 4 basket cells in cat visual cortex receive excitatory input from neighboring spiny neurons, resulting in large excitatory EPSPs. One third of spiny cell-smooth cell pair were connected reciprocally (postsynaptic targets include local spiny stellate, pyramidal cells, as well as smooth neurons), but the postsynaptic IPSPs evoked by basket cells are slower, GABAergic, probably of GABAA type (Tarczy-Hornoch K, Martin K and Jack JJ and Stratford KJ, 1998⁴⁴⁵ ).; GABA is a neurotransmitter used by basket cells or clutch cells (Somogyi and Soltesz I, 1986 [cat]⁴⁵⁰ ). Basket cells make synaptic contact with pyramidal and spiny stellate cells preferentially on the somata (50%) and dendritic shaft (45%), but synapses on dendritic spines are also present (4.9%). IPSPs elicited in the postsynaptic cells have short latency, fast rising time and short duration, similar to those mediated by GABAA receptors (Tamas and Buhl EH and Somogyi P, 1997⁴⁴⁸ ). Layer 4 basket cells in cat visual cortex receive excitatory input from neighboring spiny neurons, resulting in large excitatory EPSPs. One third of spiny cell-smooth cell pair were connected reciprocally (postsynaptic targets include local spiny stellate, pyramidal cells, as well as smooth neurons), but the postsynaptic IPSPs evoked by basket cells are slower, GABAergic, probably of GABAA type (Tarczy-Hornoch K, Martin K and Jack JJ and Stratford KJ, 1998⁴⁴⁵ ).; Autaptic self-innervation of basket cells (Tamas and Buhl EH and Somogyi P, 1997⁴⁴⁶ ).