Gene organization of ion channels

Membrane Channels: Inventory of genes and gene products

This page gives a complete overview of the main types of membrane channels that have been identified in excitable membranes. The list of membrane currents for NeuronDB is a subset of this inventory. The inventory is based on Hille (2001). The inventory is in terms of genes and gene products.

Na channels Ca channels K channels and related channels

Gene family of Na channels Biophysical properties
Channel name Human gene name Human chromosome
Na_v1.1 SCN1A 2q24

Na_v1.2 SCN2A 2q23-24

Na_v1.3 SCN3A 2q24

Na_v1.4 SCN4A 17q23-25

Na_v1.5 SCN5A 3p21

Na_v1.6 SCN8A 12q13

Na_v1.7 SCN9A 2q24

Na_v1.8 SCN10A 3p22-24

Na_v1.9 SCN11A 3p21-24

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**Gene family of Na channels** Biophysical properties
Channel name	Human gene name	Human chromosome
			Na_v1.1	SCN1A	2q24
Na_v1.2	SCN2A	2q23-24
Na_v1.3	SCN3A	2q24
Na_v1.4	SCN4A	17q23-25
Na_v1.5	SCN5A	3p21
Na_v1.6	SCN8A	12q13
Na_v1.7	SCN9A	2q24
Na_v1.8	SCN10A	3p22-24
Na_v1.9	SCN11A	3p21-24

Abbreviations:

Na_v: Sodium channel, voltage-gated

**Gene family of Ca channels**
		Channel name	Human gene name	Human chromosome
HVA	L	Ca_v1.1	CACNA1S	1q31-32
		Ca_v1.2	CACNA1C	12p13.33
		Ca_v1.3	CACNA1D	3p14.3
		Ca_v1.4	CACNA1F	Xp11.23
	P/Q	Ca_v2.1	CACNA1A	19p13
	N	Ca_v2.2	CACNA1B	9q34
	R	Ca_v2.3	CACNA1E	1q25-31
LVA T		Ca_v3.1	CACNA1G	17q22
		Ca_v3.2	CACNA1H	16p13.2
		Ca_v3.3	CACNA1I	22q12

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Abbreviations:

Ca_v: Calcium channel, voltage-gated
HVA: High voltage-activated, high-threshold
LVA: Low voltage-activated, low-threshold
L-type: Longlasting, high-threshold
T-type: Transient, low-threshold
N-type: Neither L- nor T-type.
P/Q-type: sensitive to w-Aga IVA
R-type: resistent to w-Aga IVA

**Gene family of K and related channels** Biophysical properties
	Subfamily	Human gene prefix	Phenotype	Biophysical feature
6TM	NCN1	HCN	Hyperpolarization-activated	Nonselective cation channels
	CNG1	CNG	Cyclic nucleotide-gated	Nonselective cation channels
	eag	KCNH	Voltage-gated ether a-go-go
	akt1		Plant inward rectifiers
	pak1		Paramecium
	mslo	KCNM	Large conductance (BK) voltage/calcium-gated
	SK1	KCNN	Small and intermdiate conductance calcium-activated
	Kv1.1	KCNA	Voltage-gated shakers	Delayed-rectifiers and A-type
	Kv2.1	KCNB	Voltage-gated shabs
	Kv3.1	KCNC	Voltage-gated shaws
	Kv4.1	KCND	Voltage-gated shals
	Kv5.1		Voltage-gated outlier
	Kv6.1		Modifiers/silencers
	Kv7.1=KCNQ1	KCNQX=Kv7.X	Voltage-gated KCNQs	Slow delayed-rectifiers (M-Current is a heteromeric assembly of KCNQ2 and KCNQ3 subunits)
	Kv8.1		Modifiers/silencers	Delayed-rectifiers
	Kv9.1	KCNS	Modifiers/silencers	Delayed-rectifiers
2TM	Kir4.1	KCNH	Inward rectifiers	Classical inward rectifiers
	Kir7.1
	Kir1.1
	Kir2.1
	Kir5.1
	Kir6.1			ATP-sensitive
	Kir3.1			G-protein-coupled
4TM	TWIK	KCNK	2-P-domain K leaks

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Abbreviations:

Kv: Potassium channel, voltage-gated
Kir: Inward-rectifying potassium channel
KCNQ: Potassium channel, voltage gated, originally known as KvLQT, the gene responsible for the Long QT-interval (in electrocardiograms) disease

Reference

Hille, B. (2001) Ion Channels of Excitable Membrane (3rd Edition). Sunderland, Mass. Sinauer Associates, Inc.

K channels from the cardiovascular cell physiology group at Philipps-University Marburg

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