Pathological mechanism (s) having Alzheimer as Pathology

1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
3 Abeta causes selective neuronal mortality. This requires cell membrane binding.
4 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
5 Abeta decreases dedritic spine number and alters dendritic spine morpholology
6 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
7 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
8 Abeta decreases p-21 activated kinase and causes cofilin pathology
9 Abeta inhibits late LTP in animal models of Alzheimers
10 Abeta inhibits LTP both in soluble and fibrillar conformational states
11 Abeta inhibits LTP through TNFalpha
12 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
13 Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
14 Abeta modulates A current (HEK293 cells)
15 Abeta oligomer causes aberrant activity of p-21 activated kinase
16 Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling
17 Abeta peptides block LTP in rat CA1 in vivo
18 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
19 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
20 ACh Esterase inhibitors decrease Abeta production by influencing APP processing
21 AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist.
22 Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
23 Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition
24 Alpha4beta2 receptor blockade causes memory impairment
25 AMPA receptor downscaling in AD
26 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
27 BACE1 required for LTP at mossy fiber-CA3 synapses
28 beta Amyloid increases calcium currents
29 beta Amyloid increases calcium currents (2)
30 beta-Amyloid activates I_L by MAP Kinase
31 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
32 beta-Amyloid impairs LTP/LTD
33 beta-Amyloid potentiates Ca influx through L-type Ca channels
34 beta-amyloid reduces IA
35 beta-Amyloid-induced depression of LTP attenuated by Verapamil
36 Chronic nicotine decreases NGF and improves memory performance
37 Donepezil modulates potassium channels
38 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
39 Galantamine increases dopamine release in the hippocampus
40 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.