Pathological mechanism (s) having Reduces as Pathological action

1 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
2 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
3 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
4 ACh Esterase inhibitors decrease Abeta production by influencing APP processing
5 beta-Amyloid-induced depression of LTP attenuated by Verapamil
6 Chronic nicotine decreases NGF and improves memory performance
7 Galantamine increases dopamine release in the hippocampus
8 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
9 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
10 Memantine reduces APP, Galantamine and Nicotine increase synaptophysin
11 Nicotine decreases intracellular copper concentration; attenuates Abeta toxicity
12 Phosphatidyl serine (BC-PS) decreases dendritic spine loss
13 Presenilin-1 deficient neurons have increased activity of L channels