Pathological mechanism (s) having Increases as Pathological action

1 Abeta (1-42) increases dopamine release in the prefrontal cortex
2 Abeta causes selective neuronal mortality. This requires cell membrane binding.
3 Abeta increase in A-type K+ current is caused by modulation of Kv4 subunit expression
4 Amyloid plaques increase elimination of dendritic spines
5 beta Amyloid increases calcium currents
6 beta Amyloid increases calcium currents (2)
7 DHA increases dendritic spines and synapses; enhanced by uridine and choline
8 NGF restores dendritic spine density in Layer V pyramidal neurons
9 Nicotine decreases intracellular Cu+2 concentration. Abeta increases.
10 Nicotine increases APP and APLP2 gene expression
11 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
12 Protofibrillar intermediates of ABeta change firing pattern of neurons.