Pathological mechanism (s) having I L high threshold as Channel(s)

1 beta Amyloid increases calcium currents
2 beta-Amyloid activates I_L by MAP Kinase
3 beta-Amyloid potentiates Ca influx through L-type Ca channels
4 beta-Amyloid-induced depression of LTP attenuated by Verapamil
5 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
6 Inhibition of I_L impairs LTP in CA1 in vivo
7 Okadaic acid mediates tau phosphorylation via L channel activation
8 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
9 Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
10 Presenilin-1 deficient neurons have increased activity of L channels