BrainPharm: Pathological mechanism

Pathological mechanism (s) having NMDA as Receptor(s)

	Name
1	Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
2	Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition
3	beta-Amyloid impairs LTP/LTD
4	Inhibition of I_L impairs LTP in CA1 in vivo
5	Memantine reduces APP, Galantamine and Nicotine increase synaptophysin
6	Serum magnesium level correlates with clinical deterioration in Alzheimer's

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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