Pathological mechanism (s) having NMDA as Receptor(s)

1 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
2 Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition
3 beta-Amyloid impairs LTP/LTD
4 Inhibition of I_L impairs LTP in CA1 in vivo
5 Memantine reduces APP, Galantamine and Nicotine increase synaptophysin
6 Serum magnesium level correlates with clinical deterioration in Alzheimer's