BrainPharm: Pathological mechanism

Pathological mechanism (s) having Nicotine as Pharmacological Agent

	Name
1	Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
2	Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
3	Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
4	Nicotine decreases intracellular Cu+2 concentration. Abeta increases.

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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