Pathological mechanism (s) having Cultured cortical neurons as Cell model

1 Abeta causes selective neuronal mortality. This requires cell membrane binding.
2 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
3 Presenilin-1 deficient neurons have increased activity of L channels
4 Protofibrillar intermediates of ABeta change firing pattern of neurons.