Pathological mechanism (s) having Early as Stage

1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
3 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
4 Abeta decreases dedritic spine number and alters dendritic spine morpholology
5 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
6 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
7 Abeta decreases p-21 activated kinase and causes cofilin pathology
8 Abeta inhibits late LTP in animal models of Alzheimers
9 Abeta inhibits LTP both in soluble and fibrillar conformational states
10 Abeta inhibits LTP through TNFalpha
11 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
12 Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
13 Abeta modulates A current (HEK293 cells)
14 Abeta peptides block LTP in rat CA1 in vivo
15 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
16 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
17 AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist.
18 Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
19 Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition
20 Alpha4beta2 receptor blockade causes memory impairment
21 Aluminum alters GABAA receptors
22 AMPA receptor downscaling in AD
23 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
24 BACE1 required for LTP at mossy fiber-CA3 synapses
25 beta-Amyloid activates I_L by MAP Kinase
26 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
27 beta-Amyloid potentiates Ca influx through L-type Ca channels
28 beta-amyloid reduces IA
29 beta-Amyloid-induced depression of LTP attenuated by Verapamil
30 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
31 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
32 Histidine associating compounds block Abeta Channel activity and cytotoxicity
33 Inhibition of I_L impairs LTP in CA1 in vivo
34 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
35 LTP requires BDNF and is associated with cytoskeleton-associated protein
36 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist
37 Model block of I_A
38 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
39 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
40 Picomolar concentrations of abeta monomers disrupt LTP
41 Post-synaptic Drebrin correlated with Alzheimer's cognitive decline
42 Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
43 Regulation of back-propagating action potentials in hippocampal neurons.
44 Serum magnesium level correlates with clinical deterioration in Alzheimer's
45 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice
46 Synapse Loss correlated with cognitive loss in mild Alzheimer's Disease
47 The channel hypothesis of Alzheimers disease