BrainPharm: Pathological mechanism

Pathological mechanism (s) having Nicotine as Extracelular pathological element

	Name
1	Chronic nicotine decreases NGF and improves memory performance
2	Nicotine decreases intracellular copper concentration; attenuates Abeta toxicity
3	Nicotine desensitize alpha7 nACh receptors and facilitates LTP
4	Nicotine increases APP and APLP2 gene expression

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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