Pathological mechanism (s) having beta Amyloid as Extracelular pathological element

1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
3 Abeta causes selective neuronal mortality. This requires cell membrane binding.
4 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
5 Abeta decreases dedritic spine number and alters dendritic spine morpholology
6 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
7 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
8 Abeta decreases p-21 activated kinase and causes cofilin pathology
9 Abeta inhibits late LTP in animal models of Alzheimers
10 Abeta inhibits LTP both in soluble and fibrillar conformational states
11 Abeta inhibits LTP through TNFalpha
12 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
13 Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
14 Abeta modulates A current (HEK293 cells)
15 Abeta oligomer causes aberrant activity of p-21 activated kinase
16 Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling
17 Abeta peptides block LTP in rat CA1 in vivo
18 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
19 AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist.
20 AMPA receptor downscaling in AD
21 beta Amyloid increases calcium currents (2)
22 beta-Amyloid activates I_L by MAP Kinase
23 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
24 beta-Amyloid impairs LTP/LTD
25 beta-amyloid reduces IA
26 beta-Amyloid-induced depression of LTP attenuated by Verapamil
27 Co-localization of amyloid beta and tau in Alzheimer's disease synaptosomes.
28 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
29 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
30 Histidine associating compounds block Abeta Channel activity and cytotoxicity
31 Inhibition of I_L impairs LTP in CA1 in vivo
32 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
33 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist
34 Model block of I_A
35 Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
36 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
37 Nicotine decreases intracellular Cu+2 concentration. Abeta increases.
38 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
39 Picomolar concentrations of abeta monomers disrupt LTP
40 Protective effect of donepezil against beta amyloid neurotoxicity
41 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice
42 The channel hypothesis of Alzheimers disease