BrainPharm: Pathological mechanism

Pathological mechanism (s) having p-21 activated kinase (PAK) as Intracelular pathological element

	Name
1	Abeta decreases p-21 activated kinase and causes cofilin pathology
2	Abeta oligomer causes aberrant activity of p-21 activated kinase
3	Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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