BrainPharm: Pathological mechanism

Pathological mechanism (s) having Dendritic spine density as Process

	Name
1	Abeta decreases dendritic spine number, causes dysmorphic spine shapes
2	Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
3	DHA increases dendritic spines and synapses; enhanced by uridine and choline
4	Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
5	NGF restores dendritic spine density in Layer V pyramidal neurons

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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