BrainPharm: Pathological mechanism

Pathological mechanism (s) having Decreases as Process action

	Name
1	Abeta decreases dendritic spine number, causes dysmorphic spine shapes
2	Abeta decreases p-21 activated kinase and causes cofilin pathology
3	Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
4	Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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