Pathological mechanism (s) having Synapse Loss as Hypothesis

1 Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
2 Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
3 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
4 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla