BrainPharm: Pathological mechanism

Pathological mechanism (s) having Synapse Loss as Hypothesis

	Name
1	Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
2	Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
3	Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
4	Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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