BrainPharm: Pathological mechanism

Pathological mechanism (s) having Dendritic Hypothesis - K+ current as Hypothesis

	Name
1	Abeta modulates A current (HEK293 cells)
2	beta-amyloid reduces IA
3	Donepezil modulates potassium channels
4	Model block of I_A
5	Protofibrillar intermediates of ABeta change firing pattern of neurons.

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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