Pathological mechanism (s) having Dendritic Hypothesis - Ca++ currents as Hypothesis

1 beta Amyloid increases calcium currents
2 beta Amyloid increases calcium currents (2)
3 beta-Amyloid activates I_L by MAP Kinase
4 beta-Amyloid potentiates Ca influx through L-type Ca channels
5 Okadaic acid mediates tau phosphorylation via L channel activation
6 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
7 Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
8 Presenilin-1 deficient neurons have increased activity of L channels