BrainPharm: Pathological mechanism

Pathological mechanism (s) having Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable as Claim

	Name
1	Abeta modulates A current (HEK293 cells)
2	Donepezil modulates potassium channels
3	Protofibrillar intermediates of ABeta change firing pattern of neurons.

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.

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