Pathological mechanism (s) having Loss/alteration of dendritic spines in early Alzheimer's as Claim

1 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
2 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
3 Amyloid plaques increase elimination of dendritic spines
4 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
5 DHA increases dendritic spines and synapses; enhanced by uridine and choline
6 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
7 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
8 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline
9 NGF restores dendritic spine density in Layer V pyramidal neurons