Intracellular element - List

6 A protease that cleaves amyloid precursor protein (APP) to produce beta-amyloid (1-42) which forms amyloid plaques
7 A regulator of synaptic plasticity
8 An intracellular aggregate
9 Drebrin is a widespread actin-associating protein originally identified in neuronal cells
10 Inheritance of the apolipoprotein (apo) E4 isotype of apoE is a major risk factor for late-onset AD
11 Intracellular copper concentraion
12 Mitogen activated kinases are serine/threonine-specific protein kinases that respond to extracellular stimuli (mitogens) and regulate various cellular activities, such as gene expression, mitosis, differentiation, and cell survival/apoptosis.
13 Neprilysin is a rate-limiting peptidase, which participates in the catabolism of Abeta in brain.
14 Protein kinase A refers to a family of enzymes whose activity is dependent on the level of cyclic AMP (cAMP) in the cell. PKA is also known as cAMP-dependent protein kinase.
15 Protein kinase C is a family of protein kinases consisting of ~10 isozymes.
16 Spinophilin, a protein that interacts with actin and protein phosphatase-1, is highly enriched in dendritic spines.
17 The p21-activated kinases (PAKs) 1-3 are serine/threonine protein kinases whose activity is stimulated by the binding of active Rac and Cdc42 GTPases. PAKs serve as important regulators of cytoskeletal dynamics and cell motility.
18 TLR signaling causes synaptic impairment
19 Tumor Necrosis Factor type-1: Cell death receptor