Neuronal Currents (s) having The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. High conductance KCa channels were 2-fold less Ca2+ sensitive in high-frequency than in low-frequency cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells as Publication facts

1 Cochlea hair inner GLU cell | Soma | I K,Ca
2 Cochlea hair outer GLU cell | Soma | I K,Ca