Pathological mechanism - List

1 Abeta (1-42) increases dopamine release in the prefrontal cortex
2 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
3 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
4 Abeta causes selective neuronal mortality. This requires cell membrane binding.
5 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
6 Abeta decreases dedritic spine number and alters dendritic spine morpholology
7 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
8 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
9 Abeta decreases p-21 activated kinase and causes cofilin pathology
10 Abeta increase in A-type K+ current is caused by modulation of Kv4 subunit expression
11 Abeta inhibits late LTP in animal models of Alzheimers
12 Abeta inhibits LTP both in soluble and fibrillar conformational states
13 Abeta inhibits LTP through TNFalpha
14 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
15 Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling
16 Abeta modulates A current (HEK293 cells)
17 Abeta oligomer causes aberrant activity of p-21 activated kinase
18 Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling
19 Abeta peptides block LTP in rat CA1 in vivo
20 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
21 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
22 ACh Esterase inhibitors decrease Abeta production by influencing APP processing
23 AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist.
24 Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA
25 Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition
26 Alpha4beta2 receptor blockade causes memory impairment
27 Aluminum alters GABAA receptors
28 AMPA receptor downscaling in AD
29 Amyloid plaques increase elimination of dendritic spines
30 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
31 BACE1 required for LTP at mossy fiber-CA3 synapses
32 beta Amyloid increases calcium currents
33 beta Amyloid increases calcium currents (2)
34 beta-Amyloid activates I_L by MAP Kinase
35 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
36 beta-Amyloid impairs LTP/LTD
37 beta-Amyloid potentiates Ca influx through L-type Ca channels
38 beta-amyloid reduces IA
39 beta-Amyloid-induced depression of LTP attenuated by Verapamil
40 Chronic nicotine decreases NGF and improves memory performance