Pathological mechanism (s) having Induces as Pathological action

1 Abeta decreases dedritic spine number and alters dendritic spine morpholology
2 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
3 Alpha4beta2 receptor blockade causes memory impairment
4 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
5 Histidine associating compounds block Abeta Channel activity and cytotoxicity
6 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
7 Okadaic acid mediates tau phosphorylation via L channel activation