| 1 |
Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine. |
| 2 |
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation |
| 3 |
Abeta causes selective neuronal mortality. This requires cell membrane binding. |
| 4 |
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e |
| 5 |
Abeta inhibits late LTP in animal models of Alzheimers |
| 6 |
Abeta inhibits LTP both in soluble and fibrillar conformational states |
| 7 |
Abeta inhibits LTP through TNFalpha |
| 8 |
Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals |
| 9 |
Abeta oligomer causes aberrant activity of p-21 activated kinase |
| 10 |
Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling |
| 11 |
Abeta peptides block LTP in rat CA1 in vivo |
| 12 |
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers |
| 13 |
Alpha4beta2 receptor blockade causes memory impairment |
| 14 |
AMPA receptor downscaling in AD |
| 15 |
Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density |
| 16 |
BACE1 required for LTP at mossy fiber-CA3 synapses |
| 17 |
beta Amyloid increases calcium currents |
| 18 |
beta Amyloid increases calcium currents (2) |
| 19 |
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP |
| 20 |
beta-Amyloid impairs LTP/LTD |
| 21 |
beta-Amyloid potentiates Ca influx through L-type Ca channels |
| 22 |
beta-amyloid reduces IA |
| 23 |
beta-Amyloid-induced depression of LTP attenuated by Verapamil |
| 24 |
Galantamine increases dopamine release in the hippocampus |
| 25 |
Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro. |
| 26 |
Inhibition of I_L impairs LTP in CA1 in vivo |
| 27 |
Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice |
| 28 |
LTP requires BDNF and is associated with cytoskeleton-associated protein |
| 29 |
Model block of I_A |
| 30 |
Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline |
| 31 |
Nicotine decreases intracellular copper concentration; attenuates Abeta toxicity |
| 32 |
Nicotine decreases intracellular Cu+2 concentration. Abeta increases. |
| 33 |
Nicotine desensitize alpha7 nACh receptors and facilitates LTP |
| 34 |
Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo |
| 35 |
Nicotine increases APP and APLP2 gene expression |
| 36 |
Post-synaptic Drebrin correlated with Alzheimer's cognitive decline |
| 37 |
Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity. |
| 38 |
Regulation of back-propagating action potentials in hippocampal neurons. |
| 39 |
Synapse Loss correlated with cognitive loss in mild Alzheimer's Disease |
