1 |
Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine. |
2 |
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation |
3 |
Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice |
4 |
Abeta decreases dedritic spine number and alters dendritic spine morpholology |
5 |
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e |
6 |
Abeta decreases dendritic spine number, causes dysmorphic spine shapes |
7 |
Abeta decreases p-21 activated kinase and causes cofilin pathology |
8 |
Abeta inhibits late LTP in animal models of Alzheimers |
9 |
Abeta inhibits LTP both in soluble and fibrillar conformational states |
10 |
Abeta inhibits LTP through TNFalpha |
11 |
Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals |
12 |
Abeta inhibits PAK, stimulates ROCK and impairs synapses by TLR signaling |
13 |
Abeta modulates A current (HEK293 cells) |
14 |
Abeta peptides block LTP in rat CA1 in vivo |
15 |
Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors |
16 |
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers |
17 |
AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist. |
18 |
Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA |
19 |
Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition |
20 |
Alpha4beta2 receptor blockade causes memory impairment |
21 |
Aluminum alters GABAA receptors |
22 |
AMPA receptor downscaling in AD |
23 |
Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density |
24 |
BACE1 required for LTP at mossy fiber-CA3 synapses |
25 |
beta-Amyloid activates I_L by MAP Kinase |
26 |
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP |
27 |
beta-Amyloid potentiates Ca influx through L-type Ca channels |
28 |
beta-amyloid reduces IA |
29 |
beta-Amyloid-induced depression of LTP attenuated by Verapamil |
30 |
Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease |
31 |
Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro. |
32 |
Histidine associating compounds block Abeta Channel activity and cytotoxicity |
33 |
Inhibition of I_L impairs LTP in CA1 in vivo |
34 |
Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice |
35 |
LTP requires BDNF and is associated with cytoskeleton-associated protein |
36 |
Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist |
37 |
Model block of I_A |
38 |
Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla |
39 |
Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo |
40 |
Picomolar concentrations of abeta monomers disrupt LTP |