Pathological mechanism (s) having Nicotinic Receptor Hypothesis as Hypothesis

1 Abeta (1-42) increases dopamine release in the prefrontal cortex
2 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
3 ACh Esterase inhibitors decrease Abeta production by influencing APP processing
4 AD combined treatment with cholinesterase inhibitor and alpha-adrenergic agonist.
5 Alpha4beta2 receptor blockade causes memory impairment
6 Chronic nicotine decreases NGF and improves memory performance
7 Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
8 Nicotine decreases intracellular copper concentration; attenuates Abeta toxicity
9 Nicotine decreases intracellular Cu+2 concentration. Abeta increases.
10 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
11 Nicotine increases APP and APLP2 gene expression