Pathological mechanism (s) having Dendritic Spine Hypothesis as Hypothesis

1 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
2 Abeta decreases dendritic spine number, causes dysmorphic spine shapes
3 Abeta decreases p-21 activated kinase and causes cofilin pathology
4 Abeta oligomer causes aberrant activity of p-21 activated kinase
5 Amyloid plaques increase elimination of dendritic spines
6 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
7 Co-localization of amyloid beta and tau in Alzheimer's disease synaptosomes.
8 DHA increases dendritic spines and synapses; enhanced by uridine and choline
9 Drebrin decrease causes cognitive deficits but does not affest spatial memory
10 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
11 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
12 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline
13 NGF restores dendritic spine density in Layer V pyramidal neurons
14 Phosphatidyl serine (BC-PS) decreases dendritic spine loss
15 Post-synaptic Drebrin correlated with Alzheimer's cognitive decline
16 Synapse Loss correlated with cognitive loss in mild Alzheimer's Disease