Neuronal Receptors
  • Spinal cord lumbar motor neuron alpha ACh cell Show Other
Ia afferents release GLU
  • Glu from Ia axon terminals (reviewed in Show Other
  • Intracellular recordings: CMQX and NBQX applied at the soma completely block short duration (i.e. near soma) single fiber EPSPs Show Other
  • see Burke 1998 for references). Single-fiber Ia EPSPs have widely varying shapes Show Other
  • Show Other
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  • indicating that Ia synapses are distributed widely over soma-dendrites (confirmed by HRP labelling of Ia afferents on labelled motoneurones: reviewed in Show Other
  • SOBiv p88). Glutamate is released from Ia terminals Show Other
  • Show Other
  • Ia synapses are immunoreactive for GLU Show Other
  • Ia EPSPs are mediated largely by AMPA receptors (muscle afferents: Show Other
  • single fiber EPSPs: Show Other
  • by contrast, Show Other
  • found an NMDA component in neonatal rat. Short-term post-tetanic potentiation (PTP) and depression (PTD) occur Show Other
  • but not LTP or LTD (SOBiv p90).Motoneurons have a high density of AMPA receptors (Vandenberghe et al, JNS 20: 7158, 2000). There is evidence that "glutamate receptor-mediated Ca2+ influx, intracellular Ca2+ accumulation, and subsequent cell death" may be involved in the mechanism of selective motoneuron degeneration in amyotrophic lateral sclerosis. Show Other
Other categories referring to NA-123
Revisions: 1
Last Time: 10/4/2000 12:36:00 PM
Reviewer: System Administrator
Owner: System Administrator