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Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
  • Crisp, Kevin [crisp at stolaf.edu] Show Other
Leech S Cell
Excitability
Crisp, Kevin <crisp@stolaf.edu>
False
False
Other categories referring to Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Revisions: 12
Last Time: 6/2/2016 1:34:42 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin