SenseLab
Neuronal Currents
  Data
NA-150
True
  • Sensitive to TTX. This generates the impulses that propagate into the axon Show Other
  • Simultaneous whole-cell recordings, made from the soma and dendrites rat brain slices, showed that AP evoked by either current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with increasing distance into the dendrites. Simultaneous somatic and axonal recordings showed that these action potentials were initiated in the axon Show Other
  • The kinetics properties of this current were studied using whole-cell recording from dissociated neurons. Unlike other cells, recovery from inactivation was accompanied by a sizeable ionic current. It was suggested that the current flowing during this recovery may depolarize the cells immediately after an AP, promoting the typical high-frequency firing of these neurons (complex spike) Show Other
  • NaV1.1 is present in the soma and proximal dendrites, NaV1.6 is robustly present in cell bodies and dendrites, and NaV1.7 is absent from the cell Show Other
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Other categories referring to NA-150
Revisions: 3
Last Time: 9/7/2012 4:25:17 PM
Reviewer: Tom Morse
Owner: System Administrator