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Data
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Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)
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"An intricate network of reactions is involved in matching energy supply with demand in the heart. This complexity
arises because energy production both modulates and is modulated by the electrophysiological and contractile activity of the
cardiac myocyte. Here, we present an integrated mathematical model of the cardiac cell that links excitation-contraction
coupling with mitochondrial energy generation. The dynamics of the model are described by a system of 50 ordinary differential
equations. The formulation explicitly incorporates cytoplasmic ATP-consuming processes associated with force generation and
ion transport, as well as the creatine kinase reaction. Changes in the electrical and contractile activity of the myocyte are
coupled to mitochondrial energetics through the ATP, Ca21, and Na1 concentrations in the myoplasmic and mitochondrial
matrix compartments. ..."
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Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) Show
Other
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tom.morse@yale.edu
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current
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