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A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (Sun et al. 2007)
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"Ca2+-triggered synchronous neurotransmitter release is well described, but asynchronous release-in fact, its very existence-remains enigmatic.
Here we report a quantitative description of asynchronous neurotransmitter release in calyx-of-Held synapses.
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Our results reveal that release triggered in wild-type synapses at low Ca2+ concentrations is physiologically asynchronous, and that asynchronous release completely empties the readily releasable pool of vesicles during sustained elevations of Ca2+.
We propose a dual-Ca2+-sensor model of release that quantitatively describes the contributions of synchronous and asynchronous release under conditions of different presynaptic Ca2+ dynamics."
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Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC (2007) Show
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