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A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (Sun et al. 2007)
"Ca2+-triggered synchronous neurotransmitter release is well described, but asynchronous release-in fact, its very existence-remains enigmatic. Here we report a quantitative description of asynchronous neurotransmitter release in calyx-of-Held synapses. ... Our results reveal that release triggered in wild-type synapses at low Ca2+ concentrations is physiologically asynchronous, and that asynchronous release completely empties the readily releasable pool of vesicles during sustained elevations of Ca2+. We propose a dual-Ca2+-sensor model of release that quantitatively describes the contributions of synchronous and asynchronous release under conditions of different presynaptic Ca2+ dynamics."
  • Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC (2007) Show Other
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Revisions: 6
Last Time: 9/16/2016 2:19:33 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin