Pathological mechanism

Data

Name beta Amyloid increases calcium currents (2)

Description

Hypothesis Dendritic Hypothesis - Ca++ currents Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I Calcium Show Other

Pharmacological Agent Nifedipine Show Other

Pharmacological Action Blocks Show Other

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment General or unspecified Show Other

PubMed ID 12207918

Citation Abeta(25-35) and Abeta(1-40) act on different calcium channels in CA1 hippocampal neurons. Show Other

AlzWeb

Notes "...beta-Amyloid(1-40) is related to an increase of non-L-type Ca channels ..." (Rovira C, et al. 2002).

Pathology Alzheimer Show Other

Stage

Question

Claim Increased excitability can increase Ca++ influx causing synaptic effects and excitotoxicity Show Other