Neural compartmental extracell

Data

Name beta-amyloid reduces IA

Description

Ion channel I A Show Other

Receptor(s)

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

CF-Compartment Distal apical dendrite Show Other Middle apical dendrite Show Other Proximal apical dendrite Show Other Distal basal dendrite Show Other Middle basal dendrite Show Other Proximal basal dendrite Show Other Distal oblique dendrite Show Other Middle oblique dendrite Show Other Soma Show Other

Extracellular element beta Amyloid Show Other

Affected in disease Alzheimer Show Other

References/notes Application of beta-amyloid to outside-out patches reduces the A-current; leading to increased dendritic calcium influx and loss of calcium homeostasis, potentially causing synaptic failure and initiating neuronal degenerative proceses(Chen C 2005).

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