Neural compartmental extracell

Data

Name Model block of I_A

Description

Ion channel I A Show Other

Receptor(s)

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

CF-Compartment Axon fiber Show Other Distal apical dendrite Show Other Middle apical dendrite Show Other Proximal apical dendrite Show Other Distal basal dendrite Show Other Middle basal dendrite Show Other Proximal basal dendrite Show Other Soma Show Other Axon hillock Show Other Axon terminal Show Other Distal oblique dendrite Show Other Middle oblique dendrite Show Other

Extracellular element beta Amyloid Show Other

Affected in disease Alzheimer Show Other

References/notes A model shows that block of I_A is sufficient to cause membrane depolarization, calcium influx, and increased excitability (Good TA, Murphy RM 1996).

URL

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